A late rally was not enough to earn Boston United a point at Guiseley.
Ben Milnes’ 85th minute free kick lifted spirits, but the hosts - who have a fantastic record against Boston at Nethermoor - hung on courtesy of their two finishes.
The Lions needed just 44 seconds to take the lead.
Boston’s marking was far too slack when defending Wayne Brooksby’s left-wing cross, allowing Andy Pearson the space and time to loop his header over Dan Haystead and into the net.
The Pilgrims carved out two great chances to pull level, but with Spencer Weir-Daley through on goal he was denied by Steve Drench’s fine save.
Then Ben Milnes found himself in a similar position, only to drag his strike wide of the far post.
Milnes - who was turning the screw in midfield with some delightful passing - saw a 20-yarder simply saved by Drench before the hosts went on the offensive.
Ex-Pilgrim Kevin Holsgrove was finding space in the United box, although failing to unleash a strike, while Pearson put a free header over.
On 32 minutes, Boston’s Phil Watt suffered a head injury after colliding with James Walshaw, handing a debut to Paul Lister.
It took 10 minutes for the first real chance of the second half to arrive, but Guiseley’s Josh Wilson couldn’t get enough on his header to trouble Haystead.
Then, on the hour mark, United handed out their second debut of the day as Dan Lawlor replaced Keiran Walker.
But after that it was pretty much all the Lions.
Yet another header brought yet another save from Haystead as he scrambled yet another Pearson effort round his post.
Guiseley were coming into their own and Holsgrove almost extended the lead, but Haystead did enough to deny his strike.
However, that lead was doubled in the 65th minute.
James Walshaw’s header crashed against the crossbar, only for referee’s assistant Jane Simms to flag that it had crossed the goal line on the way down.
Haystead then saved further blushes by denying Josh Wilson’s low effort .
In a rare foray at the other end, Spencer Weir-Daley’s final touch of the day was a goalbound volley... off his knee.
The Boston striker was then replaced by Jordan Smith.
Walshaw looked odds on to make it 3-0 whyen he brushed Lister aside and beat Haystead, but his powerful drive flew inches off target.
But with five minutes left Ben Milnes handed Boston a lifeline.
His 20-yard free kick took enough of a deflection to beat Steve Drench, and hand the Pilgrims a glimmer of hope.
That glimmer was almost an equaliser after Anton Foster’s run culminated in Smith’s strikle being saved.
Nathan Stainfield then saw a header fly over as the Pilgrims suddenly had a spring in their step and, in the final few seconds, Marc Newsham saw his low effort smothered.
And that was it, Guiseley held on for a deserved win and Boston left Nethermoor having won just once in 11 visits.
GUISELEY: Drench, Hardy, Meynell, Rea, Ellis, Pearson, Brooksby (Marsh 76), Holdsworth (Lawlor 87), J. Wilson, Walshaw, Holsgrove (Mcwilliams 76): Subs (not used): M. Wilson, Giles.
UNITED: Haystead, Marshall, Mayo, Foster, Watt Lister 32), Stainfield, Walker (Lawlor), Milnes, Weir-Daley (J. Smith 70), Newsham, Fairclough; Subs (not used): Ward, Reid.
Ref: Adrian Holmes.