The A52 going east bound from Bicker Bar roundabout will be closed on Monday as emergency works take place to repair a dangerous manhole cover.
The road will be closed from 9am to 3pm, however, west bound traffic will be unaffected.
A diversion route will be in place, from A52 Bicker via the B1181 on to the A17.
A Lincolnshire County Council spokesman apologised for the inconvenience and said the closure has become necessary to repair a dangerous manhole cover.
They said: “Access will be maintained to properties and businesses including a hotel, fuel station and haulage company, within the closure only.
They added: “The closure will be arranged to avoid peak traffic times, however there is likely to be some disruption so please allow more time for your journey.”
For details visit www.lincolnshire.gov.uk/roadworks or follow @LincsCC_roads on Twitter.