Gary Cross netted on his Boston Town debut as Poachers boss Dan Barrett earned his first victory since taking over dug-out duties.
Alex Beck and Renzie Lobendhan were also on target as Town left Northampton Sileby Rangers with all three UCL Premier points.
Beck grabbed his first goal since August on 13 minutes and when Lobendhan added his name to the scoresheet on the half-hour mark, the Poachers looked to have a comfortable lead.
The hosts pulled one back before the break, only for Cross to regain Boston’s two-goal advantage.
Rangers reduced the arrears again, but Town held on to end that 10-game winless run.